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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by Shawn. T. on July 16, 2002, at 14:33:56
I'm not so sure trimipramine is as great as you seem to think it is. Personally, I wouldn't poke this drug with a ten foot stick. If the number of links provided is not enough, I'll throw thirty more at you. All this drug is good for is teaching me more about serotonin receptors. Why doesn't anyone like Remeron? If you start on 7.5mg/day and keep it there for as long as possible, you'll have great luck. Mixing it with DHEA is such a nice idea for depressives. My psychiatrist has sometimes been mocked for prescribing so much Remeron, that's too bad.
Trimipramine actually an atypical neuroleptic:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1663593&dopt=AbstractOn trimipramine and learning:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8476377&dopt=AbstractOn trimipramine and seizures:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11144696&dopt=AbstractOn allergic reactions:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1857950&dopt=AbstractSimilarities to clozapine:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1979173&dopt=AbstractSome information on side effects:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1806621&dopt=AbstractOn P-450 effects:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2778096&dopt=AbstractOne poor women's experience on the drug:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2925603&dopt=Abstract
Shawn
Posted by Shawn. T. on July 16, 2002, at 14:35:39
In reply to Bad idea, posted by Shawn. T. on July 16, 2002, at 14:33:56
Posted by fachad on July 16, 2002, at 21:35:36
In reply to Bad idea, posted by Shawn. T. on July 16, 2002, at 14:33:56
Shawn,
Your posts seem very well thought out and very well researched. You seem like someone who has spent enough time in the journals to realize that all drugs have adverse effects. But I think pulling all those articles on trimipramine adverse effects was, well...unnecessarily alarmist.
I know you are fond of Remeron, so I'll do a little "right back atcha", in a playful spirit, on Remeron side effects.
I know you love the stuff, but please don't get so excited about Remeron that you wet yourself.
Urinary incontinence with mirtazapine:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12019674&dopt=AbstractI hope that last article doesn't cramp your style, or cause you to get all bent out of shape, but it looks like Remeron might do that too.
Dystonia induced by mirtazapine:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12019672&dopt=AbstractHopefully, finding out about all these problems with Remeron won't make you so nervous that you can't sit still.
Mirtazapine-induced akathisia:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11999246&dopt=AbstractMirtazapine may have the propensity for developing a restless legs syndrome? A case report:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11952928&dopt=AbstractI'm sure you get the point - this could go on and on forever for any drug. In many ways, I agree with you that Remeron is the biggest breakthrough in AD therapy in years. It is very unique in a sea of similar "me too" drugs. But it's not perfect. The weight gain side effect alone severely limits it's acceptance by many patients. No one wants to get fat.
Trimipramine is also a very unique durg among a sea of "me too" copy cat tricyclics. It's quite amazing to see the similarities to atypical APs in a drug that predates them by 30 years. And trimip is as effective at relieving depression as other TCAs, even though it does not inhibit reuptake of either 5-HT or NE; nor does it down regulate beta receptors. It too can cause weight gain. For me the weight gain from trimipramine is less that it is from Remeron. And trimpramine helps me sleep just as well as Remeron did.
So different things work for different people. That's why we say YMMV.
-fachad
> I'm not so sure trimipramine is as great as you seem to think it is. Personally, I wouldn't poke this drug with a ten foot stick. If the number of links provided is not enough, I'll throw thirty more at you. All this drug is good for is teaching me more about serotonin receptors. Why doesn't anyone like Remeron? If you start on 7.5mg/day and keep it there for as long as possible, you'll have great luck. Mixing it with DHEA is such a nice idea for depressives. My psychiatrist has sometimes been mocked for prescribing so much Remeron, that's too bad.
>
> Trimipramine actually an atypical neuroleptic:
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1663593&dopt=Abstract
>
> On trimipramine and learning:
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8476377&dopt=Abstract
>
> On trimipramine and seizures:
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11144696&dopt=Abstract
>
> On allergic reactions:
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1857950&dopt=Abstract
>
> Similarities to clozapine:
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1979173&dopt=Abstract
>
> Some information on side effects:
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1806621&dopt=Abstract
>
> On P-450 effects:
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2778096&dopt=Abstract
>
> One poor women's experience on the drug:
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2925603&dopt=Abstract
>
>
> Shawn
This is the end of the thread.
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