![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by Frankie on March 28, 2002, at 2:56:18
Hello,
I have researched that Remeron is great in conjunction with an SSRI and Buspar, if you are having anxiety induced side effects from these two. I am thinking of trying it out, because supposedly Buspar elevates the S2 serotonin receptor, and in turn aggravates anxiety at that receptor, causing some PTSD problems in individuals that already exhibit some PTSD in the first place. I do. I need some feedback from you guys that are on Remeron with an SSRI. I am not willing to gain weight, but I have ways around that. Plus, is it not true that at higher doses, Remeron is stimulating? I need something that will give me some focus too. Effexor is not an answer because it will worsen the anxiety with Celexa and Buspar. I appreciate any input with Remeron doses, combinations, etc... Thanks.
Frankie.
Posted by Janelle on March 28, 2002, at 3:03:37
In reply to Remeron with SSRI's?, posted by Frankie on March 28, 2002, at 2:56:18
Unfortunately I can"t offer you anything about the synergy between Remeron and SSRI's, in fact, I'm considering going that route myself.
However, you wrote that Buspar can CAUSE anxiety (you said it elevates the S2 serotonin receptor, and in turn aggravates anxiety at that receptor) -- this is news to me because I thought Buspar is to HELP calm anxiety? At least that is what someone I know who was having anxiety was given Buspar for!
Like you, I am not willing to gain weight, but you said that you "have ways around that" - WHAT WAYS? I'd love to know them since I may be put on a low dose of Remeron.
I don't know if it's true that Remeron is "stimulating" at high doses, all I've heard is that it loses its SEDATING properties at high doses.
Sorry I couldn't be of specific help to you. I'm curious as to your answers to my questions, though! Thanks.
Posted by JohnX2 on March 28, 2002, at 3:30:52
In reply to Remeron with SSRI's?, posted by Frankie on March 28, 2002, at 2:56:18
> Hello,
>
> I have researched that Remeron is great in conjunction with an SSRI and Buspar, if you are having anxiety induced side effects from these two. I am thinking of trying it out, because supposedly Buspar elevates the S2 serotonin receptor, and in turn aggravates anxiety at that receptor, causing some PTSD problems in individuals that already exhibit some PTSD in the first place. I do. I need some feedback from you guys that are on Remeron with an SSRI. I am not willing to gain weight, but I have ways around that. Plus, is it not true that at higher doses, Remeron is stimulating? I need something that will give me some focus too. Effexor is not an answer because it will worsen the anxiety with Celexa and Buspar. I appreciate any input with Remeron doses, combinations, etc... Thanks.
>
> Frankie.Frankie,
I'm confused about the "S2" comment.
Buspar is a partial agonist at the serotonin 5-ht1a site (its primary serotonergic action). At high doses it also has a metabolite that is an antagonist at the alpha-2 noradrenaline site (these antagonist may generally precipitate PTSD anxiety symptoms). Also Buspar is thought to be a mild dopamine d2 receptor antagonist.
John
Posted by Frankie on March 28, 2002, at 11:59:43
In reply to Re: Remeron with SSRI's? » Frankie, posted by Janelle on March 28, 2002, at 3:03:37
> Unfortunately I can"t offer you anything about the synergy between Remeron and SSRI's, in fact, I'm considering going that route myself.
>
> However, you wrote that Buspar can CAUSE anxiety (you said it elevates the S2 serotonin receptor, and in turn aggravates anxiety at that receptor) -- this is news to me because I thought Buspar is to HELP calm anxiety? At least that is what someone I know who was having anxiety was given Buspar for!
>
> Like you, I am not willing to gain weight, but you said that you "have ways around that" - WHAT WAYS? I'd love to know them since I may be put on a low dose of Remeron.
>
> I don't know if it's true that Remeron is "stimulating" at high doses, all I've heard is that it loses its SEDATING properties at high doses.
>
> Sorry I couldn't be of specific help to you. I'm curious as to your answers to my questions, though! Thanks.Janelle,
Buspar is an antianxiety medication. But, it only helps generalized anxiety disorder. It does nothing for panic attacks, PTSD, OCD, or any other phobia. However, in people with PTSD, it can worsen that condition. If someone is on Buspar, and gets moody with a dosage increase, or anxious, then they have an elevated S2 receptor. If they can tolerate this medication well, then they don't have any PTSD problems. Understand? As to the other part of your question, the ways around the weight gain. A few things. 1.) Eat smaller, more frequent meals. 2.) Cut carbohydrates down. 3.) Start a good excercise regimen. 4.) Cut out late night meals and snacks.
Frankie.
Posted by Frankie on March 28, 2002, at 12:04:53
In reply to Re: Remeron with SSRI's?, posted by JohnX2 on March 28, 2002, at 3:30:52
> > Hello,
> >
> > I have researched that Remeron is great in conjunction with an SSRI and Buspar, if you are having anxiety induced side effects from these two. I am thinking of trying it out, because supposedly Buspar elevates the S2 serotonin receptor, and in turn aggravates anxiety at that receptor, causing some PTSD problems in individuals that already exhibit some PTSD in the first place. I do. I need some feedback from you guys that are on Remeron with an SSRI. I am not willing to gain weight, but I have ways around that. Plus, is it not true that at higher doses, Remeron is stimulating? I need something that will give me some focus too. Effexor is not an answer because it will worsen the anxiety with Celexa and Buspar. I appreciate any input with Remeron doses, combinations, etc... Thanks.
> >
> > Frankie.
>
> Frankie,
>
> I'm confused about the "S2" comment.
>
> Buspar is a partial agonist at the serotonin 5-ht1a site (its primary serotonergic action). At high doses it also has a metabolite that is an antagonist at the alpha-2 noradrenaline site (these antagonist may generally precipitate PTSD anxiety symptoms). Also Buspar is thought to be a mild dopamine d2 receptor antagonist.
>
> JohnJohn,
Yes, you are correct. It is throught the activity of that alpha 2 receptor that the PTSD is aggravated. However, I don't believe that the dosage must be high as you say to stimulate that receptor. I think it may deal with the combination of meds one is on, plus the length of time that it is taken to build up in the bloodstream.
Frankie.
Posted by JohnX2 on March 28, 2002, at 19:49:44
In reply to Re: Remeron with SSRI's?, posted by Frankie on March 28, 2002, at 12:04:53
> > > Hello,
> > >
> > > I have researched that Remeron is great in conjunction with an SSRI and Buspar, if you are having anxiety induced side effects from these two. I am thinking of trying it out, because supposedly Buspar elevates the S2 serotonin receptor, and in turn aggravates anxiety at that receptor, causing some PTSD problems in individuals that already exhibit some PTSD in the first place. I do. I need some feedback from you guys that are on Remeron with an SSRI. I am not willing to gain weight, but I have ways around that. Plus, is it not true that at higher doses, Remeron is stimulating? I need something that will give me some focus too. Effexor is not an answer because it will worsen the anxiety with Celexa and Buspar. I appreciate any input with Remeron doses, combinations, etc... Thanks.
> > >
> > > Frankie.
> >
> > Frankie,
> >
> > I'm confused about the "S2" comment.
> >
> > Buspar is a partial agonist at the serotonin 5-ht1a site (its primary serotonergic action). At high doses it also has a metabolite that is an antagonist at the alpha-2 noradrenaline site (these antagonist may generally precipitate PTSD anxiety symptoms). Also Buspar is thought to be a mild dopamine d2 receptor antagonist.
> >
> > John
>
> John,
>
> Yes, you are correct. It is throught the activity of that alpha 2 receptor that the PTSD is aggravated. However, I don't believe that the dosage must be high as you say to stimulate that receptor. I think it may deal with the combination of meds one is on, plus the length of time that it is taken to build up in the bloodstream.
>
> Frankie.yeah, it would be nice if they made a buspar without that side metabolite. I wonder how that medicine would stack up in terms of efficacy on anxiety if it ditched the alpha-2 stimulation?
Remeron antagonizes the alpha-2 receptor also.
John
Posted by OldSchool on March 28, 2002, at 21:08:19
In reply to Remeron with SSRI's?, posted by Frankie on March 28, 2002, at 2:56:18
> Hello,
>
> I have researched that Remeron is great in conjunction with an SSRI and Buspar, if you are having anxiety induced side effects from these two. I am thinking of trying it out, because supposedly Buspar elevates the S2 serotonin receptor, and in turn aggravates anxiety at that receptor, causing some PTSD problems in individuals that already exhibit some PTSD in the first place. I do. I need some feedback from you guys that are on Remeron with an SSRI. I am not willing to gain weight, but I have ways around that. Plus, is it not true that at higher doses, Remeron is stimulating? I need something that will give me some focus too. Effexor is not an answer because it will worsen the anxiety with Celexa and Buspar. I appreciate any input with Remeron doses, combinations, etc... Thanks.
>
> Frankie.Sure it can be done. Once I combined 45 mg Remeron with 200 mg Zoloft.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.