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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by 3 Beer Effect on February 7, 2002, at 13:29:01
Is Lamictal really activating or is it sedating, because on the side effect profile there is a much larger incidence of Somnolence & Dizziness than there is of insomnia (6%).
I am just starting out on Lamictal on 25 mg/day & increasing by 25 mg each week.
I take 4 mg of Klonopin per day for social phobia in the day & insomnia at night= 1 at breakfast, 1 at lunch, & 2 an hour before bedtime.
I take Provigil 200 mg in the morning which I believe wakes you up by increasing the action/amount of glutamate? Lamictal decreases the action of glutamate so wouldn't they be just canceling each other out? What makes Lamictal activating, if it is so?
Posted by Hattree on February 7, 2002, at 13:50:31
In reply to Lamictal once/day-- take at night or morning?, posted by 3 Beer Effect on February 7, 2002, at 13:29:01
Don't know what makes Lamictal activating for some--it doesn't seem to have much effect one way or another for me, except for keeping depression at bay, which it does quite well. Also seems to help a little with stimulant poop-out.
> Is Lamictal really activating or is it sedating, because on the side effect profile there is a much larger incidence of Somnolence & Dizziness than there is of insomnia (6%).
>
> I am just starting out on Lamictal on 25 mg/day & increasing by 25 mg each week.
> I take 4 mg of Klonopin per day for social phobia in the day & insomnia at night= 1 at breakfast, 1 at lunch, & 2 an hour before bedtime.
> I take Provigil 200 mg in the morning which I believe wakes you up by increasing the action/amount of glutamate? Lamictal decreases the action of glutamate so wouldn't they be just canceling each other out? What makes Lamictal activating, if it is so?
Posted by JohnX2 on February 7, 2002, at 17:50:20
In reply to Re: Lamictal once/day-- take at night or morning?, posted by Hattree on February 7, 2002, at 13:50:31
Hi 3 beer,I read an abstract recently that Lamictal
increases brain levels of the amino acid taurine.
Taurine is a weak nmda antagonist.
This would help with stimulant poop out.I had really bad stimulant poop out on Adderall and found that
Klonopin removed the poop out. Since then I found
lots of research papers that gabaergic meds can help
alleviate stimulant sensitization. Also meds
that antagonize nmda receptors. When I recently
added Topamax (a gabaA enhancer + AMPA glutamate
mediator) to my Lamictal, I found that the combo
completely removed my tolerance to stimulants
(at least caffeine and pseudo-ephedrine). Haven't
tested other stimulant like amphetamines, but
I used to build up tolerance to pseudoephedrine
in 2-3 days.In regards to the Lamictal, it seems once one
gets to a healty dose ( greater than 100 mg) the
amount in the body won't waver much depending on
the time of day the medicine is taken. That's one
thing that is really nice about the medicine; the
once a day dosing.Regards,
John
> Don't know what makes Lamictal activating for some--it doesn't seem to have much effect one way or another for me, except for keeping depression at bay, which it does quite well. Also seems to help a little with stimulant poop-out.
>
>
> > Is Lamictal really activating or is it sedating, because on the side effect profile there is a much larger incidence of Somnolence & Dizziness than there is of insomnia (6%).
> >
> > I am just starting out on Lamictal on 25 mg/day & increasing by 25 mg each week.
> > I take 4 mg of Klonopin per day for social phobia in the day & insomnia at night= 1 at breakfast, 1 at lunch, & 2 an hour before bedtime.
> > I take Provigil 200 mg in the morning which I believe wakes you up by increasing the action/amount of glutamate? Lamictal decreases the action of glutamate so wouldn't they be just canceling each other out? What makes Lamictal activating, if it is so?
This is the end of the thread.
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