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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by ross on November 29, 2001, at 10:38:28
zyprexa--mood stabilzer.plus excellent for social anxiety
klonopin--my benzo for anxiety and socialness
zoloft--again A/D
remeron--again A/D
valium prn--just in case
cut out neurontin in place of zyprexa. zyrexa much better for mood stab...
Posted by JohnX2 on November 29, 2001, at 21:21:08
In reply to my new augment strategy, posted by ross on November 29, 2001, at 10:38:28
Ross,Interesting cocktail. Curiously the Remeron
will have an interesting tug of war with the
Zyprexa. The alpha-2 antagonism in Remeron will
increase serotonin firing in an area of the
brain called the raphe nucleus. The alpha-1
antagonism in zyprexa (which makes you drowsy)
depresses firing of serotonin in the same area.
Both meds antagonize (block) similar sertonin
receptors (the 5ht-2 series).Good luck.
I had a nutty combo that was based on a theory
to pound away dopamine firing along a particular
path in the brain (all these meds have been
shown to increase firing in the locus coerulus
and the VTA and increase dopamine in the prefrontal
cortex..sorry for the scientfic mumbo jumbo).Here it went:
Remeron,Manerix,Selegiline,Reboxetine.
Worked awesome and fast, but it is dangerous
to combine the Remeron with the Maoi inhibitors
and I would get a racing heart when I ate the
wrong foods. I also tried taking a little
psuedoephedrine on top of this to make it a show
stopper and I got a response that was a dead
ringer to amphetamine. I stopped the med combo
because I ran out of meds. Anyways most of the
meds by themselves sucked but I figured the combo
would have massive synergy and it did.
I probably could have blown my brain away if
I added Effexor on top. ;)-john
> zyprexa--mood stabilzer.plus excellent for social anxiety
> klonopin--my benzo for anxiety and socialness
> zoloft--again A/D
> remeron--again A/D
> valium prn--just in case
> cut out neurontin in place of zyprexa. zyrexa much better for mood stab...
Posted by JGalt on December 1, 2001, at 11:13:35
In reply to Re: my new augment strategy, posted by JohnX2 on November 29, 2001, at 21:21:08
Wow John, that sounds like a lot of fun...I would have added some real ephedrine and caffeine on top, maybe some yohimbine just for kicks (and to counteract ephedrine's occasional impotence side effects and selegiline's orthostatic hypotension side effect), maybe some nicotine too...
I don't suppose you got your doc to approve that combination though, did you?
JGalt
Posted by JohnX2 on December 1, 2001, at 20:38:50
In reply to Re: my new augment strategy, posted by JGalt on December 1, 2001, at 11:13:35
> Wow John, that sounds like a lot of fun...I would have added some real ephedrine and caffeine on top, maybe some yohimbine just for kicks (and to counteract ephedrine's occasional impotence side effects and selegiline's orthostatic hypotension side effect), maybe some nicotine too...
>
> I don't suppose you got your doc to approve that combination though, did you?Let's just say I was bored at the time and
leave it at that. I wanted to see if i could
mimick a stimulant. Block the alpha-2 feedback
receptor with Remeron to keep the neuron making
the good stuff and firing. Increase the good stuff
production with the MAOI inhibitor, and block the
reuptake of the goods with Reboxetine. Use
a sympathomimetic med like pseudoephedrine and
ya got something like Adderall....Then you throw in a beta blocker when your pulse
goes to 120 beats per second. LOL.-john
>
> JGalt
Posted by christophrejmc on December 1, 2001, at 21:19:30
In reply to Re: my new augment strategy, posted by JohnX2 on November 29, 2001, at 21:21:08
May I ask why you combined Manerix and selegiline?
> Remeron,Manerix,Selegiline,Reboxetine.
Posted by JohnX2 on December 2, 2001, at 11:55:05
In reply to Re: my new augment strategy » JohnX2, posted by christophrejmc on December 1, 2001, at 21:19:30
Manerix is a reversible MAO-A inhibitor.
It does not have dietary restrictions by itself.
Selegiline is a MAO-B inhibitor at the
lower doses, and MAO-A at the higher dose,
but it has the dietary restrictions.
I wanted to see if I could get away with as
little Selegiline as possible, but I pretty
much needed 60 mg to get the full effect.I found that I needed a healthy dose of
both to get this to work. I had more Manerix
on hand, so I had to budget the Selegiline.I could probably have swapped the 2 out for
Parnate.I think I've heard of someone else combining
Parnate with a NRI. (was it SLS?).Reboxetine is supposed to help prevent
a hypertensive crisis on a MAOI and is actually
a safner from what I read. But I don't know
if that is true with the alpha-2 antagonist
from Remeron in there.When the MAOI inhibitor causes more amine
to be released, or a reuptake inhibitor
is leaving more amine in the synaptic cleft,
normally it would hit the alpha-2 feedback
receptor which I believe would
decreased the tyrosine hydroxylase in the
presynaptic neuron (the rate limiting enzyme
to produce dopamine or noradrenaline). With
the alpha-2 antagonist, the reuptake inhibitor,
and MAOI inhibitor, its pretty much balls to
the wall on output. But I think it could be
toxic and dangerous.-john
> May I ask why you combined Manerix and selegiline?
> > Remeron,Manerix,Selegiline,Reboxetine.
This is the end of the thread.
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