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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by JohnX2 on November 11, 2001, at 14:41:24
Somewhat amusing talk about the roots of PTSD,
memory encoding, synaptic plasticity.
Interestingly in the discussion they specifically
cover lamotrigine as a treatment for PTSD. They
didn't talk about NMDA antagonists which would also
be interesting imho.http://www.psychiatrist.com/supplenet/v61s05/610504.htm#Discussion
Posted by JohnX2 on November 11, 2001, at 15:10:11
In reply to discussion on PTSD, learning, plastic, posted by JohnX2 on November 11, 2001, at 14:41:24
Hmm, maybe there is too much off this plastic
crap in my brain. I believe Serzone made me a
dummy, but I was a drunk, painless,
and happy dummy. Its actions must have
antagonized neuronal plasticitiy.As a side note, these chronic tension headaches
I got started 3 weeks after taking large supplements
of flax-oil and fish oil. The supplements had a substantial
effect on my mood at 1st , very similar to SSRIS.
I felt a little tired but much less anxious. One
day I woke up and BOOM, permanant tension headaches.
Attenuated when I dropped the flax seed oil, but
now anything that was an anti-depressant like
Zoloft,Wellbutrin,and even flax seed oil makes my
headache worse. Klonopin,Serzone,Zyprexa make things
better. In fact I have challenged the Zyprexa with
Wellbutrin and it mitigates the headache an even
minor dose of Wellbutrin would normally give me.
I think this is related more to the alpha-1 and
5ht-2a antagonism, and somehow indirect the nmda
receptors. I challenged Klonopin with Zoloft and
it mitigated Zoloft emotional numbing and side
effects. Wondering if I should dose Zoloft in
with the Zyprexa to see if I can wipe out the
dysthymia. I have no leftovers like the wellbutrin
to test out, and the doc said no.Does the omega-3 fish oil affect synaptic plasticity,
anyone, anyone ?thanks for any info to help unfoobar me.
-john>
> Somewhat amusing talk about the roots of PTSD,
> memory encoding, synaptic plasticity.
> Interestingly in the discussion they specifically
> cover lamotrigine as a treatment for PTSD. They
> didn't talk about NMDA antagonists which would also
> be interesting imho.
>
> http://www.psychiatrist.com/supplenet/v61s05/610504.htm#Discussion
Posted by JohnX2 on November 11, 2001, at 15:17:43
In reply to Re: discussion on PTSD, learning, plastic - Omeg3, posted by JohnX2 on November 11, 2001, at 15:10:11
PS the supplement DMAE (acetylcholine precursor)
is the worst-case scenario for driving my head
into *screaming pain*. High doses of benadryl
or other anti-cholinergics attenuate the pain
as well as the zyprexa,klonopin,and serzone.I wish those $300/hr doctors could put 2 @ 2
together to get me a good treatment. There is
a very clear pattern in my mind, even with my
limited knowledge of psychopharmacology. I'm
starting to get fed up with debating with them
on my treatment ultimately to walk out the door
with a script I could have chosen myself.Maybe its all psychosomatic, I'm sure they are
thinking...arghhh.
-john>
> Hmm, maybe there is too much off this plastic
> crap in my brain. I believe Serzone made me a
> dummy, but I was a drunk, painless,
> and happy dummy. Its actions must have
> antagonized neuronal plasticitiy.
>
> As a side note, these chronic tension headaches
> I got started 3 weeks after taking large supplements
> of flax-oil and fish oil. The supplements had a substantial
> effect on my mood at 1st , very similar to SSRIS.
> I felt a little tired but much less anxious. One
> day I woke up and BOOM, permanant tension headaches.
> Attenuated when I dropped the flax seed oil, but
> now anything that was an anti-depressant like
> Zoloft,Wellbutrin,and even flax seed oil makes my
> headache worse. Klonopin,Serzone,Zyprexa make things
> better. In fact I have challenged the Zyprexa with
> Wellbutrin and it mitigates the headache an even
> minor dose of Wellbutrin would normally give me.
> I think this is related more to the alpha-1 and
> 5ht-2a antagonism, and somehow indirect the nmda
> receptors. I challenged Klonopin with Zoloft and
> it mitigated Zoloft emotional numbing and side
> effects. Wondering if I should dose Zoloft in
> with the Zyprexa to see if I can wipe out the
> dysthymia. I have no leftovers like the wellbutrin
> to test out, and the doc said no.
>
> Does the omega-3 fish oil affect synaptic plasticity,
> anyone, anyone ?
>
> thanks for any info to help unfoobar me.
> -john
>
> >
> > Somewhat amusing talk about the roots of PTSD,
> > memory encoding, synaptic plasticity.
> > Interestingly in the discussion they specifically
> > cover lamotrigine as a treatment for PTSD. They
> > didn't talk about NMDA antagonists which would also
> > be interesting imho.
> >
> > http://www.psychiatrist.com/supplenet/v61s05/610504.htm#Discussion
Posted by judy1 on November 12, 2001, at 17:57:15
In reply to Re: discussion on PTSD, learning, plastic - Omeg3, posted by JohnX2 on November 11, 2001, at 15:17:43
Hi John,
What are your feelings about Ecstasy trials for PTSD? Thanks- judy
Posted by JohnX2 on November 13, 2001, at 18:03:41
In reply to Re: discussion on PTSD, learning, plastic - Omeg3 » JohnX2, posted by judy1 on November 12, 2001, at 17:57:15
I would love to be in "Ecstacsy", but
I suppose you are referring to the drug.
Is that one MDMA?-john
> Hi John,
> What are your feelings about Ecstasy trials for PTSD? Thanks- judy
Posted by judy1 on November 13, 2001, at 19:06:42
In reply to Re: discussion on PTSD, learning, plastic - Omeg3 » judy1, posted by JohnX2 on November 13, 2001, at 18:03:41
Posted by JohnX2 on November 13, 2001, at 23:22:39
In reply to Re: discussion on PTSD, learning, plastic - Omeg3 » judy1, posted by JohnX2 on November 13, 2001, at 18:03:41
I'm afraid I haven't been there (Ecstasy).
Closesest was probably the d-amphetamine
buzz in Adderall. A couple good life
experiences count too, I guess. ;)Whats X like? I hear it is like a combo
of a gaba/serotonin drug and amphetamine. I.e.
makes you more relaxed and at ease but
motivated and sociable at the same time.
Too bad it can cause permament brain damage,
not that enough speed won't on its own.also, always wondered how much more
potent meth-amphetamine (speed?) is than plain old
dextro-amphetamine (upper?).
Never tried meth. Only the prescription Adderall.
Did I get the street vernacular right?-john
>
> I would love to be in "Ecstacsy", but
> I suppose you are referring to the drug.
> Is that one MDMA?
>
> -john
>
>
> > Hi John,
> > What are your feelings about Ecstasy trials for PTSD? Thanks- judy
Posted by JGalt on November 14, 2001, at 19:57:45
In reply to Re: discussion on PTSD, learning, plastic - Omeg3 » JohnX2, posted by JohnX2 on November 13, 2001, at 23:22:39
Last time I checked, John, Adderal was Methamphetamine+Dextroamphetamine, two salts of each. The idea behind this was supposed to be that the meth would get to work immediately, while the dex would take longer to take effect. Thus, you've already experienced methamphetamine. I wonder at what level the methamphetamine in adderal causes dopamine depletion and permanent brain damage?
Ecstacy was once used as a marital counseling drug. Just saw this on the history channel the other day. The couple would be given a low level of it and then go spend some time together. Was said that the couple learned that they did love one another again, and that they could understand each other and love each other better even after the high wore off (though this may have been a little romantasized by the counselors)...said to have the same effect as a year in good therapy.
According to that site I sent ya a while back, continous SSRI use leads to the same types of damages as X, obviously at a much slower rate though (but then again X isn't usually used daily). Wish there was some more studies on this.
Posted by JohnX2 on November 17, 2001, at 6:57:48
In reply to Re: discussion on PTSD, learning, plastic - Omeg3, posted by JGalt on November 14, 2001, at 19:57:45
No methamphetamine in Adderall.
Different salts of aspartate,hcl,sulfate,blah.
Racemic i.e. contains l-amphetamine and d-amphetamine.Basically a patent to protect profits.
They probably could just as easily make
a sustained released dexedrine
(plain old d-amphetamine sulfate), if it
doesn't already exist.I actually bumped into a sales rep for
Adderall at an appt about 1 month back.
He told me it was going off patent next year.
So, they are coming out with a new one
Adderall XR to get a new patent and charge
more money.-john
> Last time I checked, John, Adderal was Methamphetamine+Dextroamphetamine, two salts of each. The idea behind this was supposed to be that the meth would get to work immediately, while the dex would take longer to take effect. Thus, you've already experienced methamphetamine. I wonder at what level the methamphetamine in adderal causes dopamine depletion and permanent brain damage?
>
> Ecstacy was once used as a marital counseling drug. Just saw this on the history channel the other day. The couple would be given a low level of it and then go spend some time together. Was said that the couple learned that they did love one another again, and that they could understand each other and love each other better even after the high wore off (though this may have been a little romantasized by the counselors)...said to have the same effect as a year in good therapy.
>
> According to that site I sent ya a while back, continous SSRI use leads to the same types of damages as X, obviously at a much slower rate though (but then again X isn't usually used daily). Wish there was some more studies on this.
This is the end of the thread.
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