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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by JohnX2 on November 5, 2001, at 0:50:37
A company is actually trying to get
a pharmaceutical composed of dextromethorphan
and quinidine (cyp450 2d6 inhibitor) approved
for emotional lability and cns disorders.That patent I dug up as an amusement is actually
being used for a pharmaceutical to be
marketed as NeuroDex.http://www.avanir.com/cms/index.php?CategoryName=Neurodex
whaddaya know.
-john
Posted by JGalt on November 5, 2001, at 19:50:30
In reply to neurodex, posted by JohnX2 on November 5, 2001, at 0:50:37
Interesting. How long do you think I'd have to fake chronic cough for to be admitted into the trails? jk ;-)
I say its a great idea provided that it comes out cheaper than memantine (and given that its just a combination of 2 already widely used drugs I would imagine it would be cheaper). After reading through some of those patents its a wonder why someone didn't do this a long time ago.
Posted by SLS on November 6, 2001, at 13:21:45
In reply to Re: neurodex, posted by JGalt on November 5, 2001, at 19:50:30
> Interesting. How long do you think I'd have to fake chronic cough for to be admitted into the trails? jk ;-)
>
> I say its a great idea provided that it comes out cheaper than memantine (and given that its just a combination of 2 already widely used drugs I would imagine it would be cheaper). After reading through some of those patents its a wonder why someone didn't do this a long time ago.
Hi guys.Thanks for all the great info!
What enzyme inhibitor do you think they use?
Overall, how would you compare dextromethorphan with memantine - efficacy, side effects, drug interactions, toxicity...? Can memantine be used with an MAOI?
Thanks.
- Scott
Posted by JohnX2 on November 6, 2001, at 23:13:35
In reply to Re: neurodex, posted by SLS on November 6, 2001, at 13:21:45
I have the german- >english translated memantine
pdr if you are interested, it didn't list too
many interactions accept with other drugs
like baclofen, and anti-parkinson drugs.
Suggested possible kidney complications.
Unfortunately it didn't show detailed information
about the metabolism. That other link I posted
from a research supplier of memantine had more
information about the medicine in clinical trials,etc.I found out the hard way not to take dxm with
an maoi. Really goofed up my system.The adjunctive med to dxm was quinidine and
required only about 1/30-1/40 the therapeutic dose
of quindine for heart related problems to
achieve the enzyme inhibition. Alpha-2 and
GabaA agonists protect against nmda hypoactivity
induced neurotoxicity. I was thinking it might
be novel to try a combo of dxm,quinindine,tenex,
and adderall. A lot of the information I described
is covered in detail in patents I discovered
about nmda antagonists, if you set up an email
accnt, I'll forward the information.-john
> > Interesting. How long do you think I'd have to fake chronic cough for to be admitted into the trails? jk ;-)
> >
> > I say its a great idea provided that it comes out cheaper than memantine (and given that its just a combination of 2 already widely used drugs I would imagine it would be cheaper). After reading through some of those patents its a wonder why someone didn't do this a long time ago.
>
>
> Hi guys.
>
> Thanks for all the great info!
>
> What enzyme inhibitor do you think they use?
>
> Overall, how would you compare dextromethorphan with memantine - efficacy, side effects, drug interactions, toxicity...? Can memantine be used with an MAOI?
>
> Thanks.
>
>
> - Scott
Posted by jay on November 7, 2001, at 0:37:57
In reply to neurodex, posted by JohnX2 on November 5, 2001, at 0:50:37
Dextromethorphan is the cough syrup, right? So am I getting a real buzz when I gulp back the stuff along with codiene and my Effexor? :P..yum yum..
(I usually pound back a couple times the rec. dose also:-)Jay
>
> A company is actually trying to get
> a pharmaceutical composed of dextromethorphan
> and quinidine (cyp450 2d6 inhibitor) approved
> for emotional lability and cns disorders.
>
> That patent I dug up as an amusement is actually
> being used for a pharmaceutical to be
> marketed as NeuroDex.
>
> http://www.avanir.com/cms/index.php?CategoryName=Neurodex
>
> whaddaya know.
>
> -john
Posted by SLS on November 7, 2001, at 15:53:55
In reply to Re: neurodex » SLS, posted by JohnX2 on November 6, 2001, at 23:13:35
>
> I have the german- >english translated memantine
> pdr if you are interested, it didn't list too
> many interactions accept with other drugs
> like baclofen, and anti-parkinson drugs.
> Suggested possible kidney complications.
> Unfortunately it didn't show detailed information
> about the metabolism. That other link I posted
> from a research supplier of memantine had more
> information about the medicine in clinical trials,etc.
>
> I found out the hard way not to take dxm with
> an maoi. Really goofed up my system.
>
> The adjunctive med to dxm was quinidine and
> required only about 1/30-1/40 the therapeutic dose
> of quindine for heart related problems to
> achieve the enzyme inhibition. Alpha-2 and
> GabaA agonists protect against nmda hypoactivity
> induced neurotoxicity. I was thinking it might
> be novel to try a combo of dxm,quinindine,tenex,
> and adderall. A lot of the information I described
> is covered in detail in patents I discovered
> about nmda antagonists, if you set up an email
> accnt, I'll forward the information.
>
> -john
Thanks John.I would be grateful to have you send me some of this stuff. You can find me at:
I have no idea what this patent stuff is all about.
If you do come across anything relating to combining MAOIs and memantine, please let me know. By the way, what is it about dextromethorphan that makes it dangerous to add to an MAOI?
- Scott
Posted by Cam W. on November 7, 2001, at 23:50:34
In reply to Re: neurodex » JohnX2, posted by SLS on November 7, 2001, at 15:53:55
> If you do come across anything relating to combining MAOIs and memantine, please let me know. By the way, what is it about dextromethorphan that makes it dangerous to add to an MAOI?
>
>
> - ScottScott - Excitation, seizures, delirium, hyperpyrexia (high fever), circulatory collapse, coma, and death. A couple of fatalities have been reported with DM and phenelzine. - Cam
Posted by JohnX2 on November 10, 2001, at 9:49:28
In reply to Re: neurodex » JohnX2, posted by SLS on November 7, 2001, at 15:53:55
Scott,You should have received the documents
in cpc format. I hope i didn't flood your
email box.
Let me know if there was any problem.
Hopefully the infomation is usefull.-john
> >
> > I have the german- >english translated memantine
> > pdr if you are interested, it didn't list too
> > many interactions accept with other drugs
> > like baclofen, and anti-parkinson drugs.
> > Suggested possible kidney complications.
> > Unfortunately it didn't show detailed information
> > about the metabolism. That other link I posted
> > from a research supplier of memantine had more
> > information about the medicine in clinical trials,etc.
> >
> > I found out the hard way not to take dxm with
> > an maoi. Really goofed up my system.
> >
> > The adjunctive med to dxm was quinidine and
> > required only about 1/30-1/40 the therapeutic dose
> > of quindine for heart related problems to
> > achieve the enzyme inhibition. Alpha-2 and
> > GabaA agonists protect against nmda hypoactivity
> > induced neurotoxicity. I was thinking it might
> > be novel to try a combo of dxm,quinindine,tenex,
> > and adderall. A lot of the information I described
> > is covered in detail in patents I discovered
> > about nmda antagonists, if you set up an email
> > accnt, I'll forward the information.
> >
> > -john
>
>
> Thanks John.
>
> I would be grateful to have you send me some of this stuff. You can find me at:
>
> sl.schofield@att.net
>
> I have no idea what this patent stuff is all about.
>
> If you do come across anything relating to combining MAOIs and memantine, please let me know. By the way, what is it about dextromethorphan that makes it dangerous to add to an MAOI?
>
>
> - Scott
Posted by SLS on November 10, 2001, at 11:13:59
In reply to Re: neurodex » SLS, posted by Cam W. on November 7, 2001, at 23:50:34
> > If you do come across anything relating to combining MAOIs and memantine, please let me know. By the way, what is it about dextromethorphan that makes it dangerous to add to an MAOI?
> >
> >
> > - Scott
>
> Scott - Excitation, seizures, delirium, hyperpyrexia (high fever), circulatory collapse, coma, and death. A couple of fatalities have been reported with DM and phenelzine. - Cam
Hi Camarooski.I am curious as to what are the pharmacodynamics that cause these things.
Thanks.
- Scott
Posted by SLS on November 10, 2001, at 11:18:04
In reply to Re: neurodex » SLS, posted by JohnX2 on November 10, 2001, at 9:49:28
>
> Scott,
>
> You should have received the documents
> in cpc format. I hope i didn't flood your
> email box.
> Let me know if there was any problem.
> Hopefully the infomation is usefull.
>
> -johnThanks John!
My mailbox looks like a room full of Christmas presents. I can't wait to open them.
I will be gone for about a week. I'm taking a trip to Washington D.C. to see some friends. I have been feeling somewhat better the last few days, so I thought I'd take advantage of it. Hopefully I'll be able to pop in every now and then.
Until then...
Sincerely,
Scott
Posted by Cam W. on November 10, 2001, at 14:07:01
In reply to Re: neurodex » Cam W., posted by SLS on November 10, 2001, at 11:13:59
> I am curious as to what are the pharmacodynamics that cause these things.
>
> Thanks.
>
>
> - ScottScott - Ya gotta think it's a catacholminergic reaction. Probably it's due to increases in all three (NE, DA, & 5-HT). You can see a bit of each in the side effects, particularily dopamine and serotonin. Outside of these guesses, I don't know. - Cam
This is the end of the thread.
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