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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by kregpark@yahoo.com on October 20, 2001, at 16:54:14
Question for anyone:
Does anyone use lamictal for treating primary generalized Social Phobia?
If so would be very interested any feedback.
Thanks.
kregpark
Posted by JahL on October 20, 2001, at 20:23:16
In reply to Question: lamictal for primary Social Phobia?, posted by kregpark@yahoo.com on October 20, 2001, at 16:54:14
> Question for anyone:
>
> Does anyone use lamictal for treating primary generalized Social Phobia?
>
> If so would be very interested any feedback.Hi.
When I started taking Lamictal back in March I enjoyed, after only a few wks on 25mg, somewhere in the region of a 30% improvement in BPII symptomology, of which S. Phobia is a significant part. It was this that probably demonstrated the most pronounced improvement. I became pretty confident at the time (tho' confidence isn't an issue), but was possibly bordering on slight hypomania (which, strangely enough, I could induce almost at will with the addtn of Klonopin. For myself at least, there exists a synergy btwn the two.). Unfortunately these benefits largely faded over the course of 6 wks or so, never to rtn (I still take it for mood-stabilization & for its slight cognitive benefits).
I've tried all the 'standard' treatments; Nardil, Clomipramine, Paxil, Klonopin, Neurontin etc but only Sulpiride (100mg) offers me consistent, if incomplete relief. Also helps with ruminations.
J.
Posted by kregpark@yahoo.com on October 21, 2001, at 0:50:19
In reply to Re: answer: lamictal for primary Social Phobia? » kregpark@yahoo.com, posted by JahL on October 20, 2001, at 20:23:16
Thanks for the comments Jah, :)
Much appreciated. Sort of coincides with a couple other posts I saw where lamictal and klonopin were used together with some success.
Also your info on sulpiride.. it is the other med I have been interested in while doing a bit of digging while off work for a week this last week.
(Wellbutrin, lamictal, and amilsupride are the ones catching my interest mainly).
I've used only Wellbutrin (quite a bit here and there but not continually).Lamictal is available in US, and apprarently amisulpride is available overseas.
I think it's awaiting approval in US also.
I will check out amilsulpride on medline.Thanks again
Kreg> Hi.
>
> When I started taking Lamictal back in March I enjoyed, after only a few wks on 25mg, somewhere in the region of a 30% improvement in BPII symptomology, of which S. Phobia is a significant part. It was this that probably demonstrated the most pronounced improvement. I became pretty confident at the time (tho' confidence isn't an issue), but was possibly bordering on slight hypomania (which, strangely enough, I could induce almost at will with the addtn of Klonopin. For myself at least, there exists a synergy btwn the two.). Unfortunately these benefits largely faded over the course of 6 wks or so, never to rtn (I still take it for mood-stabilization & for its slight cognitive benefits).
>
> I've tried all the 'standard' treatments; Nardil, Clomipramine, Paxil, Klonopin, Neurontin etc but only Sulpiride (100mg) offers me consistent, if incomplete relief. Also helps with ruminations.
>
> J.
Posted by JahL on October 21, 2001, at 11:46:05
In reply to Re: answer: lamictal for primary Social Phobia? » JahL, posted by kregpark@yahoo.com on October 21, 2001, at 0:50:19
> Much appreciated. Sort of coincides with a couple other posts I saw where lamictal and klonopin were used together with some success.
>
> Also your info on sulpiride.. it is the other med I have been interested in while doing a bit of digging while off work for a week this last week.
> (Wellbutrin, lamictal, and amilsupride are the ones catching my interest mainly).
> I've used only Wellbutrin (quite a bit here and there but not continually).I've just tried Wellbutrin. Did nothing for anxiety tho' its activating profile helped a little with the motivation side of things.
> Lamictal is available in US, and apprarently amisulpride is available overseas.
> I think it's awaiting approval in US also.
> I will check out amilsulpride on medline.You know Sulpiride & Amisulpiride are different drugs, right? Sulpiride is a selective antagonist of D3 whereas Amisulpiride antagonizes D2 & D3 (I think I've got that right).
Some people here have had success with Amisulpride here but despite their similar pharmacological profiles, Sulp. & Amisulp. aren't necessarily interchangable since I didn't respond to the latter.
I've tried a few APs & the only other one I responded to, more positively than with Sulp. I might add, was Promazine, a weak AP used primarily as a sedative. It worked w/in 2 hrs but unacceptable side-effects made me stop.
It's odd that I should only respond to the older, weaker APs, but there you go.
J.
Posted by kregpark@yahoo.com on October 21, 2001, at 14:46:22
In reply to Re: answer: lamictal for primary Social Phobia? » kregpark@yahoo.com, posted by JahL on October 21, 2001, at 11:46:05
> I've just tried Wellbutrin. Did nothing for anxiety tho' its activating profile helped a little with the motivation side of things.
>
> You know Sulpiride & Amisulpiride are different drugs, right? Sulpiride is a selective antagonist of D3 whereas Amisulpiride antagonizes D2 & D3 (I think I've got that right).
=======
No, I didn't! Thanks for that very much!
I researched and printed Medline stuff on amisulpride last night but now I know about sulpiride.
I'll check it out later.
=====
> Some people here have had success with Amisulpride here but despite their similar pharmacological profiles, Sulp. & Amisulp. aren't necessarily interchangable since I didn't respond to the latter.
>
> I've tried a few APs & the only other one I responded to, more positively than with Sulp. I might add, was Promazine, a weak AP used primarily as a sedative. It worked w/in 2 hrs but unacceptable side-effects made me stop.
>
> It's odd that I should only respond to the older, weaker APs, but there you go.
=======
I would guess, (looking forward to reading on it) that sulpiride is more activating based on the description.
A D3 antagonist almost sounds a bit like an inverse, reduced toxicity apomorphine to me.
Or maybe a bit like Provigil, a very selective (and indirect) *presumably* partial 5ht-3 agonist.
Enough theory. Often just leads no-where. Anyway.
Thanks again! I will check it out.I am having more optomism about knocking down some of my still remaining mild or moderate dysthymia thing that's I've had so long!
kregpark@yahoo.com
http://www.socialfear.com/
>
> J.
Posted by kregpark@yahoo.com on October 21, 2001, at 15:12:13
In reply to Re: answer: lamictal for primary Social Phobia? » kregpark@yahoo.com, posted by JahL on October 21, 2001, at 11:46:05
Just did a quick look but looks like maybe sulpiride is d2 antagonist primarily.
Maybe is more sedating than amilsulpiride at low dose?
Interesting, and I never would have known about these meds were it not for these posts...
Posted by JahL on October 21, 2001, at 17:11:54
In reply to Re: sulpiride, d2 antagonist? » JahL, posted by kregpark@yahoo.com on October 21, 2001, at 15:12:13
> Just did a quick look but looks like maybe sulpiride is d2 antagonist primarily.
I could've sworn my pdoc said it was preferential for D3. Then again he said there was no possibility of TD, something the rsch papers don't seem to bear out. You know that Amisulp & Sulp work differently @ low doses, working as pre-synaptic antagonists?
> Maybe is more sedating than amisulpiride at low dose?
I have no problems with sedation @ 100mg. Sedation starts to set in around the 200mg mark but this higher dose yields no further benefits anyway. Funnily enough it was Amisulp that left me feeling groggy.
J.
Posted by kregpark@yahoo.com on October 22, 2001, at 3:17:47
In reply to Re: sulpiride, d2 antagonist?, posted by JahL on October 21, 2001, at 17:11:54
> > Just did a quick look but looks like maybe sulpiride is d2 antagonist primarily.
>
> I could've sworn my pdoc said it was preferential for D3. Then again he said there was no possibility of TD, something the rsch papers don't seem to bear out. You know that Amisulp & Sulp work differently @ low doses, working as pre-synaptic antagonists?
>
> > Maybe is more sedating than amisulpiride at low dose?
>
> I have no problems with sedation @ 100mg. Sedation starts to set in around the 200mg mark but this higher dose yields no further benefits anyway. Funnily enough it was Amisulp that left me feeling groggy.
>
> J.------
I'm going to look into these this week and order either or both this week.
Thanks. I'll post when (and if, I think will happen) I try one of these out low dose.
This is the end of the thread.
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