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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by Else on July 21, 2001, at 20:12:53
I know Nardil does. I've had an enthusiastic but short-lived try at Parnate and have not had the time to determine whether it impairs sexual function or not. Before I get my hopes up to high about obtaining it, I would just like to know how it rates on a scale of one to ten, 1 being Dexedrine and 10 being (ech!)Zoloft in terms of sexual side-effects. (I this question weird?)
Posted by SalArmy4me on July 21, 2001, at 20:15:18
In reply to Does PARNATE cause sexual side effects?, posted by Else on July 21, 2001, at 20:12:53
Parnate made me impotent and anorgasmic. Go for moclobemide.
> I know Nardil does. I've had an enthusiastic but short-lived try at Parnate and have not had the time to determine whether it impairs sexual function or not. Before I get my hopes up to high about obtaining it, I would just like to know how it rates on a scale of one to ten, 1 being Dexedrine and 10 being (ech!)Zoloft in terms of sexual side-effects. (I this question weird?)
Posted by Michael K on July 21, 2001, at 22:07:39
In reply to Re: Does PARNATE cause sexual side effects?, posted by SalArmy4me on July 21, 2001, at 20:15:18
> Parnate made me impotent and anorgasmic. Go for moclobemide.
>
> > I know Nardil does. I've had an enthusiastic but short-lived try at Parnate and have not had the time to determine whether it impairs sexual function or not. Before I get my hopes up to high about obtaining it, I would just like to know how it rates on a scale of one to ten, 1 being Dexedrine and 10 being (ech!)Zoloft in terms of sexual side-effects. (I this question weird?)Else,
I have been on Parnate for most of the past 13 years. I had very few problems at 40 mg (plus I was younger then). I now take 70 mg and suffer from low libido and some impotence. However, I've also taken benzos for almost all of that time as well as Trazodone for sleep. It might be the combination that's the problem, I don't know. I do know that I added 15 mg Ritalin daily about 4 months ago and things are much better now. Hope this helps. Sorry I can't give you a 1 to 10 rating since I couldn't tolerate SSRI's (or anything else anymore), but I had no sexual problems with Tricyclics when I could tolerate them.
Posted by Elizabeth on July 21, 2001, at 22:43:37
In reply to Re: Does PARNATE cause sexual side effects?, posted by Michael K on July 21, 2001, at 22:07:39
I took as much as 60 mg/day of Parnate and it did not cause me any problems in that area. On the other hand, neither did Prozac or the other SSRIs I tried.
BTW, moclobemide should not be considered a viable substitute for Nardil or Parnate.
-elizabeth
Posted by Neal on July 22, 2001, at 0:05:33
In reply to Re: Does PARNATE cause sexual side effects?, posted by Elizabeth on July 21, 2001, at 22:43:37
BTW, moclobemide should not be considered a viable substitute for Nardil or Parnate.
>
> -elizabethI'm sorry to hear that, since moclobemide dosen't have any food restrictions. Why is it not a viable substitute?
Neal
Posted by Else on July 22, 2001, at 9:21:16
In reply to Re: Moclobemide » Elizabeth, posted by Neal on July 22, 2001, at 0:05:33
My doctor told me at recommended doses, it is not very effective. At higher doses, it may be but then it becomes as dangerous as other MAOIs.
> BTW, moclobemide should not be considered a viable substitute for Nardil or Parnate.
> >
> > -elizabeth
>
> I'm sorry to hear that, since moclobemide dosen't have any food restrictions. Why is it not a viable substitute?
>
> Neal
Posted by Else on July 22, 2001, at 9:26:15
In reply to Re: Does PARNATE cause sexual side effects?, posted by Elizabeth on July 21, 2001, at 22:43:37
Hearing from you and Michael K is a relief. I just figured, maybe the dopamine increase is sufficient to cancel out the effects of increased serotonin. But you know what, I'm not sure Prozac caused problems for me either when I took it like 7 years ago. I read something about the sexual side effects of fluoxetine decreasing over time but not those of other SSRI's. I don't remember where I saw this but if someone has any info I would be glad to hear it.
> I took as much as 60 mg/day of Parnate and it did not cause me any problems in that area. On the other hand, neither did Prozac or the other SSRIs I tried.
>
> BTW, moclobemide should not be considered a viable substitute for Nardil or Parnate.
>
> -elizabeth
Posted by Elizabeth on July 22, 2001, at 12:31:24
In reply to Re: Moclobemide » Elizabeth, posted by Neal on July 22, 2001, at 0:05:33
> BTW, moclobemide should not be considered a viable substitute for Nardil or Parnate.
>
> I'm sorry to hear that, since moclobemide dosen't have any food restrictions. Why is it not a viable substitute?The list of foods that you actually need to avoid is pretty minimal -- I can post if you like. (I took MAOIs for the better part of 5 years -- at various times, Nardil, Parnate, Marplan, and selegiline -- so I've made a point of doing my research.)
Moclobemide's reputation is that it just doesn't have the same efficacy as Nardil or Parnate in treatment-resistant depression, although because of its safety profile and relative ease of use it can be a first- or second-line treatment for depression and some anxiety disorders.
Of course, Nardil and Parnate aren't really identical either. Nardil has more of an anxiolytic effect (IMO; there are pharmacological reasons why this would be the case), while Parnate has more of a stimulant-type effect (the pharmacological reason hasn't been determined; there isn't much research being done anymore on these old drugs).
-elizabeth
Posted by Elizabeth on July 22, 2001, at 12:57:53
In reply to Re: Does PARNATE cause sexual side effects?, posted by Else on July 22, 2001, at 9:26:15
> Hearing from you and Michael K is a relief. I just figured, maybe the dopamine increase is sufficient to cancel out the effects of increased serotonin. But you know what, I'm not sure Prozac caused problems for me either when I took it like 7 years ago.
Prozac didn't cause me problems. (But then again, I was only a teenager at the time (1990-'92).)
My impression from reading people's accounts is that Parnate is less likely than Nardil to cause sexual dysfunction. I don't think there are any statistics available, though.
-elizabeth
Posted by Kim on July 24, 2001, at 0:23:32
In reply to Re: Does PARNATE cause sexual side effects? » Else, posted by Elizabeth on July 22, 2001, at 12:57:53
One of the good things about Parnate, for me, is that it doesn't cause any of the sexual side effects. I've taken it for 4-5 years now, and never had problems until my pdoc added a tricyclic to the Parnate.
BTW, MAOIs are not as scary as some people make them sound. The latest research has cut way back on the amount of "forbidden" foods. IMHO, the benefits far outweigh the theoretical risks.
Kim
Posted by Else on July 24, 2001, at 6:21:02
In reply to Re: Does PARNATE cause sexual side effects?, posted by Kim on July 24, 2001, at 0:23:32
Thank you Kim,
Knowing you were on it for 5 years without any major problem provides further reassurance for me. My doctor might be interested in finding this out. It seems these drugs are almost never prescribed here.
> One of the good things about Parnate, for me, is that it doesn't cause any of the sexual side effects. I've taken it for 4-5 years now, and never had problems until my pdoc added a tricyclic to the Parnate.
>
> BTW, MAOIs are not as scary as some people make them sound. The latest research has cut way back on the amount of "forbidden" foods. IMHO, the benefits far outweigh the theoretical risks.
>
> Kim
Posted by dave_fox on July 28, 2001, at 11:16:57
In reply to Re: Moclobemide » Neal, posted by Else on July 22, 2001, at 9:21:16
> My doctor told me at recommended doses, it is not very effective. At higher doses, it may be but then it becomes as dangerous as other MAOIs. <
This is not exactly right. Moclobemide is eckoned to have seven or eight times less sensitivity to tyramine and this is considered to make it sufficiently safe. I think the trials for this were conducted at a daily dose of 600 mg. I know some people go to 900mg or even higher but the argument doesn't change that much.
However, there is some debate on whether Moclobemide is as effective as the non-reversible MAOIs like parnate. There is not much conclusive info about this comparison at the moment.
Just my opinion.
dave
This is the end of the thread.
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