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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by MarieMurph on May 10, 2001, at 13:22:09
My 11 year old brother was given ativan simutaneously while being weened off of paxil. My family and I were all expecting him to act calm and feel less anxious. However, the ativan did the opposite. It made my brother act soo angry, mad, he was screaming and swearing...(and he NEVER swears!)... so i asked a friend who is a mental health nurse. She said that sometimes people have opposite or advers effects to ativaan and it makes them do thing out of the ordinary and scary. Has anyone heard of this, or had it happen to themself?? thanks-- MARIE
Posted by PaulB on May 11, 2001, at 19:31:33
In reply to Advers Affects of Ativan, posted by MarieMurph on May 10, 2001, at 13:22:09
> My 11 year old brother was given ativan simutaneously while being weened off of paxil. My family and I were all expecting him to act calm and feel less anxious. However, the ativan did the opposite. It made my brother act soo angry, mad, he was screaming and swearing...(and he NEVER swears!)... so i asked a friend who is a mental health nurse. She said that sometimes people have opposite or advers effects to ativaan and it makes them do thing out of the ordinary and scary. Has anyone heard of this, or had it happen to themself?? thanks-- MARIE
I dont think thats all that uncommon with the benzodiapines. Stimulating GABA with Ativan does calm people down but I think it can unbalance other important chemicals involved in regulating mood in the brain-serotonin, noradrenaline and/or dopamine. You have to be careful. Good luck.
Paul B
Posted by SalArmy4me on May 12, 2001, at 14:24:41
In reply to Advers Affects of Ativan, posted by MarieMurph on May 10, 2001, at 13:22:09
There are some reports of increased anger with lorazepam (the exception--not the norm, I believe). One clinical trial suggests it can increase negative symptoms:
Garcia C. Micallef J. Dubreuil D. Philippot P. Jouve E. Blin O. Effects of lorazepam on emotional reactivity, performance, and vigilance in subjects with high or low anxiety. Journal of Clinical Psychopharmacology. 20(2):226-33, 2000 Apr.
"...The results suggest that at the doses studied, lorazepam led to an increase in negative emotions and a decrease in positive emotions, compared with placebo..."Another study:
Garcia C. Philippot P. Lacarelle B. Valli M. Rime B. Bruguerolle B. Blin O. Effects of lorazepam on film-induced differentiated emotions in healthy volunteers. Fundamental & Clinical Pharmacology. 11(5):466-75, 1997.
"On the Differential Emotions Scale and during fear induction, lorazepam induced a significantly higher increase in fear, anxiety and disgust emotions than placebo..."
This is the end of the thread.
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