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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by AndrewB on September 12, 2000, at 1:51:51
I have a 1 ml ampule of TRH (Protirelin) that I want to dilute according to instructions to make a nasal spray.
Simple question: How do you open these solid glass ampules without spilling the contents or spreading glass. There is a blue line and a red line going around the top of the vial. Is the head of the vial lopped off at one of these marks. Or maybe it is simply snapped or cut off?
Thank you,
AndrewB
Posted by Cam W. on September 12, 2000, at 6:33:17
In reply to Q for CamW, posted by AndrewB on September 12, 2000, at 1:51:51
Andrew - Cool, an answer that I know! Hold the vial vertically and flick it gently with you finger, to get all the liquid into the larger part of the vial. Using a small file or a finishing nail (or anything that will scratch the glass), score a mark horizontally across the thinnest portion of the ampoule (either the blue or red line usually). Just scratch the glass; it doesn't need to be deep. Then, firmly holding the vial upright (from the bottom, take a face cloth (or wadded paper towel) in you other hand and snap off the top.
The scoring of the vial makes it easier to break, as you are really ruining the integrity of the glass and making a weak point, which should cause the vial to fracture along the scoring. The face cloth is so that if the break isn't clean you will not drive the ampoule through your hand.
In other words, score the vial along the thinnest portion and snap off the top (using the above precautions).
Hope this helps - Cam
Posted by stjames on September 12, 2000, at 12:14:00
In reply to Q for CamW, posted by AndrewB on September 12, 2000, at 1:51:51
> I have a 1 ml ampule of TRH (Protirelin) that I want to dilute according to instructions to make a nasal spray.
>James here....
i would be intrested in knowing what you are
hoping to do with this, what effect it would
have, and on what condition. It is a dignostic med as best I understand.james
Posted by AndrewB on September 12, 2000, at 16:13:52
In reply to Re: Q for CamW, posted by stjames on September 12, 2000, at 12:14:00
James,
TRH, when diluted and applied nasally has an action upon certain receptors in the nasal cavity. Exaclty is unclear to me though it probably acts as an antagonist to the NMDA recpetors. This action may create a cascade of events effecting other neurotranmitters. By whichever means however, it apparently has a modulatory effect upon the neurotransmission on dopamine, serotonin, noradrenaline and other neurotransmitters. Anyway, the end result is that it acts, for many, to increase alertness and enhance mood, all in very rapid fashion. BTW, TRH nasal spray’s main use is to mitigate the symptoms of Multiple Chemical Sensitivity. Of course, TRH is normally used as a diagnostic for thyroid function.
I am looking at TRH, ketamine nasal spray, oxytocin nasal spray and cycloserine in order to better understand there potential in for mitigating treatment resistant depression, cognitive deficit and anergia.
For more info on TRH nasal spray:
http://www.drjgoldstein.com/frames/05artbook.htmlwww.med.cornell.edu/research/htmls/Gabriel%20K%20Tsuboyama.html
http://www.ncchem.com/review_mcs.htm
Best regards,AndrewB
Posted by stjames on September 13, 2000, at 2:15:11
In reply to Re: James There, posted by AndrewB on September 12, 2000, at 16:13:52
> James,
>
> TRH, when diluted and applied nasally has an action upon certain receptors in the nasal cavity. Exaclty is unclear to me though it probably acts as an antagonist to the NMDA recpetors. This action may create a cascade of events effecting other neurotranmitters. By whichever means however, it apparently has a modulatory effect upon the neurotransmission on dopamine, serotonin, noradrenaline and other neurotransmitters. Anyway, the end result is that it acts, for many, to increase alertness and enhance mood, all in very rapid fashion. BTW, TRH nasal spray’s main use is to mitigate the symptoms of Multiple Chemical Sensitivity. Of course, TRH is normally used as a diagnostic for thyroid function.
>james here....
Cool, what do you think about Vasopressin ? I liked it, too much
of a hassel to keep up with. You might find http://www.pharmcentral.com/nootropics.htm
of intrest. Lays it out nicely. I'm glad you are here. It is good to hear from someone
who really does the research and is willing to make an informed choice to try some novel
approches. WE know there must be other pathways to depression. I suspect something in endro
will turn up. Something more specific than sex and other kinds of steroids.James
Posted by mark on September 18, 2000, at 17:04:12
In reply to Re: Q for CamW » AndrewB, posted by Cam W. on September 12, 2000, at 6:33:17
Hi Cam,
No question or anything. I'm new to the 'babble'
and have only been around a month or so. But I really appreciate what you do for us. I personally get alot out of what you say. I'm glad you're around.Mark
Posted by Cam W. on September 18, 2000, at 22:51:54
In reply to Re: Q for CamW » Cam W., posted by mark on September 18, 2000, at 17:04:12
Mark - Thanks - Cam
This is the end of the thread.
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