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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by ryan_s on March 7, 2000, at 0:09:07
i am trying to compile a list of new or novel antidepressants. the ad that you choose to list can be domestic or overseas. furthermore, please list the receptor that is influenced by the antidepressant, a pharmacy (domestic or overseas) where the ad can be purchased, and a description of your personal experience while on the medication (if you have had experience). thanks for all of your help. hopefully this list will help refractory depressants get the medication that they deserve.
ryan_s
Posted by medlib on March 7, 2000, at 4:28:25
In reply to BRAINSTORM: novel antidepressants , posted by ryan_s on March 7, 2000, at 0:09:07
ryan-
I know that you are trying sincerely to provide a valuable service to other sufferers, but I hope you will rethink your brainstorm. The people on this board provide a unique collection of anecdotal clinical experiences in order to try to help one another. But when you try to disect their "data" from the whole of their "experience", you are left with a self-selected dataset with a very small "N"--a sample from which no researcher can usefully generalize.Neurotransmitter activity of meds is an interesting piece of the "puzzle", but I know of no reputable psych professional who would make that info their primary decision point; I believe that anyone who prescribes for himself on the basis of that alone is "malpracticing".
I think it was Pope who said "A little knowledge is a dangerous thing." (I'm too lazy to look it up). Until we can come up with the psych equivalent of the "Unified Field Theory" to explain the individual variability of treatment responses, psych will have to remain an "Art." That doesn't make it less valuable, just more individual, less susceptible to generalization.
I think the most useful treatment application of this board's info is finding individuals' stories which resonate for you and using their rx experiences as a "talking hypothesis" with your psych pro.
Whew! Climbing down off my soapbox, I DO think some may find a database of overseas drugs and sources very helpful.
Geez! I think I just made contact with how difficult it is for me to disagree with someone, after a life-long pattern of simply withdrawing. I don't mean to discourage or offend.
medlibI am trying to compile a list of new or novel antidepressants. the ad that you choose to list can be domestic or overseas. furthermore, please list the receptor that is influenced by the antidepressant, a pharmacy (domestic or overseas) where the ad can be purchased, and a description of your personal experience while on the medication (if you have had experience). thanks for all of your help. hopefully this list will help refractory depressants get the medication that they deserve.
>
> ryan_s
Posted by CarolAnn on March 7, 2000, at 7:36:51
In reply to BRAINSTORM: novel antidepressants , posted by ryan_s on March 7, 2000, at 0:09:07
Ryan, this is a good idea, but what makes it even more difficult is the fact that every AD effects almost every person who takes it differently. For example: I take 400 mgs/day of Wellbutrin, which effects dopamine and is supposed to be stimulating as well as decreasing appetite. Unfortunately, my response has been very atypical. I gained weight on it, and was still so fatigued that my Pdoc had to add a stimulant, Adderall. He also just added Celexa, an SSRI, because, though my mood had shown improvement, I have still been mainly depressed. CarolAnn
Posted by Sherry on March 7, 2000, at 10:41:26
In reply to Re: BRAINSTORM: novel antidepressants , posted by CarolAnn on March 7, 2000, at 7:36:51
And I thought I was the only one experienced a weight gain on Wellbutrin. I also experienced the fatigue. Since I have had a hard time tolerating many of the AD's, and Wellbutrin was one that I could tolerate, I wish that my pdoc would've tried augmentation. I even took it a the max dose which amazes me, but, unfortunately, it did not do much to improve my mood. Hope the augmentation helps you!!!!
Posted by JohnL on March 8, 2000, at 2:34:36
In reply to BRAINSTORM: novel antidepressants , posted by ryan_s on March 7, 2000, at 0:09:07
> i am trying to compile a list of new or novel antidepressants. the ad that you choose to list can be domestic or overseas. furthermore, please list the receptor that is influenced by the antidepressant, a pharmacy (domestic or overseas) where the ad can be purchased, and a description of your personal experience while on the medication (if you have had experience). thanks for all of your help. hopefully this list will help refractory depressants get the medication that they deserve.
>
> ryan_sRyan, some novel antidepressants might include Amisulpride, Tianeptine, Adrafinil, Modafinil, Viloxazine. Except for Viloxazine, there is a fair amount of information on these in a net search to further explore specifics. There is some evidence the nootropics can be an alternative way to treat depressive symptoms too. Specifically Hydergine, and possibly some others in the nootropic class. Again, a net search will provide specifics too lengthy to mention here.
A persistent net search will unveil some pharmacies where these various things can be purchased. Doing a search of 'german pharmacies', I actually found four that would mailorder Amisulpride to USA, with a faxed prescription. Not to mention if someone were to net search pharmacies of other countries. I know there's one in Great Britain, one in Switzerland, one in Thailand, and a couple others I don't remember. Just have to search around.
In the end though I think it really doesn't make any difference. From what I've seen, only trial and error will provide evidence of whether a particular drug is targeting our unique chemistry or not. It's cool to understand what a drug does and how it does it, but that really becomes irrelevent when we actually take the drug. What any particular drug does in one's own unique chemistry is impossible to predict, I think. In my opinion what is more important is to probe to see what class of drugs seems to work best (serotonin AD? NE AD? Antipsychotic? Stimulant? Anticonvulsant? etc), and then try to find the best match within that class. Or a blend of the best matches from two or three different classes.
I think it really is an art more than a science.
This is the end of the thread.
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