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Dr. Bob is Robert Hsiung, MD,
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Posted by Erik Hanson on December 4, 1999, at 8:03:10
Hi all. The anticholinergic side effects of reboxetine
do seem to be the problem--they are the reason I stopped
taking it (from Edronax) after an otherwise adequate
trial. Does anyone know if high dose nicotine (trans-
dermal or other non-tobacco source) or DMAE or choline
could counteract the anticholinergic effects? Why is
it that there isn't some strategy out there to reverse
the anticholinergic effects? Does anyone know specifically
which muscarinic receptor subtypes reboxetine binds to?
Maybe this info. isn't in the literature yet.Erik H.
Posted by Elizabeth on December 4, 1999, at 10:06:44
In reply to counteracting reboxetine's anticholinergic FX, posted by Erik Hanson on December 4, 1999, at 8:03:10
I don't know too much about reboxetine, but I suspect that what you're getting is the standard sympathomimetic/parasympatholytic effect that one frequently sees with noradrenergic drugs.
But anyway there is a drug called bethanechol which your doctor can prescribe; it's the standard treatment for anticholinergic side effects. Alternatively, if it's one particular side effect that's bothering you, you could just deal with that one (constipation, dry mouth, rapid heartbeat, etc.).
Posted by saint james on December 4, 1999, at 19:34:42
In reply to counteracting reboxetine's anticholinergic FX, posted by Erik Hanson on December 4, 1999, at 8:03:10
> Hi all. The anticholinergic side effects of reboxetine
> do seem to be the problem--they are the reason I stopped
> taking it (from Edronax) after an otherwise adequate
> trial.James here....
After a few months I get used to the anticholinergic effects, these effects also become much less. At this point what AC effects I do get are a great benifit to my allergies. In fact if I have a big allergy attack I will switch from Remerom to a TCA at night. Much more effective than antihistamines and often I don't have to use cortisone to bring my allergies under control.
james
This is the end of the thread.
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