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Dr. Bob is Robert Hsiung, MD,
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Posted by MA on August 4, 1999, at 12:12:56
In reply to Re: Selegiline for depression?(Brandon), posted by Robin on August 4, 1999, at 9:33:46
Our dog was on Seliegiline for Cushings disease.
He took one pill a day at the cost of about $3.50, so it is a very expensive drug.Out of curiosity I asked the vet about this because my father had been on it for Parkinson's disease. She said it was the same drug. I was trying to find out if I could substitute the human drug for the animal one to see if I could reduce the cost of treating the dog.
The problem was that I would have had to give the dog many human pills to make up for the one animal pill.Unfortunately our dog passed away about a month ago, so I did not have to pursue the cost issue.
I'm just so amazed that a pill my dog took for one disease was prescribed for my father for another and now I see it is being used for depression, which I have. Maybe, I'll end up taking it myself.
Life is so strange...
Posted by Rick on August 5, 1999, at 3:33:26
In reply to Selegiline is great!, posted by Brandon on July 19, 1999, at 20:55:14
First off, a disclaimer: I've only done a cursory
browsing of the Selegeline posts.As I mentioned in another thread, my pdoc
(surprisingly) gave me Selegeline for Social
Anxiety, after Nardil quickly pooped out but
created troublesome, long-lasting side effects.
The Selegeline was a total bust after four weeks
(at 15mg). No reduction whatsoever in my Social
Phobia (BTW, I am not clinically depressed).There WERE some pleasant (!) side effects, such as
increased libido and intensified sexual sensations
(nice!), as well as some needed (mild) lowering of
my blood pressure. No bad side effects.But since there was zilch improvement in the
Social Anxiety, I went off the Selegeline (Cold
Turkey's O.K. at 15 mg), and insisted he let me
try Klonopin (currently 2mg/day). Fairly
promising results after about a week. But then I
suggested (to my rather perplexed pdoc) that I add
back some low-dose Selegeline for mildly
hypotensive effects and possible sexual/cognitive
effects...and WOW! I don't know if this will
last, but the Social Phobia is virtually gone; my
confidence and concentration are currently through
the roof (despite minimal sleep of late, owing to
ultra-busy-ness, NOT insomnia or mania), libido
sky-high, and BP down (though not quite
enough...may move from 5mg. to 10mg. of
Selegeline...still low enough to avoid the MAOI
food restrictions...OR add pindolol...but I'm
afraid to mess with such success!) Of course,
Selegeline's fabled life-extension and
brain-protection qualities don't hurt either. I
probably shouldn't have written this; I'm rarely
superstitious, but for some reason I'm afraid I'll
jinx the wonderfully effective combination I
concocted!Maybe Selegeline works best for augmenting other
meds in mental problems, just as it serves as a
levodopa (sp?) potentiator for Parkinson's. Just
a thought. (As always, YMMV) Of course, your
doctor would have to carefully assess any possible
adverse reactions/dangerous combinations.In any event, I'm excited about the
Klonopin/Selegeline combo. Has anyone else used
this for Social Anxiety, or have I discovered a
"magic combo"?
Posted by Brandon on August 5, 1999, at 11:21:26
In reply to Re: Selegiline for depression?(Brandon), posted by Robin on August 4, 1999, at 9:33:46
I only take the generic form. There is some debate whether selegiline itself is as bioavailable as eldepryl. I personally have noticed that eldepryl did cause a slight bit more anxiety than the generic form. Otherwise unless you noticed no effect from the generic I would stick with it. The brand name is very expensive. I just ordered the discoverey liquid form from an overseas source in England. It is supposedly far superior in it's efficacy and side effect profile. We'll see! It took about 3wks. to work up to my current dose. I should warn you that selegiline is quite activating and may cause uncomfortable anxiety. Good luck with convincing your doc to prescribe it, most in my area have not heard of its use in psychiatric health. It took a couple of sessions for me to talk him into it. Hope this helps!Brandon
Posted by Rick on August 6, 1999, at 3:03:20
In reply to Re: Selegiline for depression?(Robin), posted by Brandon on August 5, 1999, at 11:21:26
I had just the opposite situation. When my Nardil
quicky pooped out for Social Phobia, the pdoc said
"I'm really not supposed to do this (!), but I'm
going to add some Eldepryl (actually Selegeline)
to smooth out the effects of the Nardil." I said
"huh?"I had never even heard of Eldepryl. He claims
it's widely used for Depression and Social Phobia
in Europe. Hell, if even non-selective
Moclobemide (sp?) is getting less than rave
reviews, how could Selegeline do the trick? Thank
God I'm now off of Nardil and onto Klonopin (plus
a small dose of Selegeline -- my own idea, as per
my previous post).Rick
>
> I only take the generic form. There is
some debate whether selegiline itself is as
bioavailable as eldepryl. I personally have
noticed that eldepryl did cause a slight bit more
anxiety than the generic form. Otherwise unless
you noticed no effect from the generic I would
stick with it. The brand name is very expensive.
I just ordered the discoverey liquid form from an
overseas source in England. It is supposedly far
superior in it's efficacy and side effect profile.
We'll see! It took about 3wks. to work up to my
current dose. I should warn you that selegiline
is quite activating and may cause uncomfortable
anxiety. Good luck with convincing your doc to
prescribe it, most in my area have not heard of
its use in psychiatric health. It took a couple
of sessions for me to talk him into it. Hope this
helps!
>
> Brandon
>
Posted by Adrian on August 8, 1999, at 5:18:43
In reply to Re: What about Moclobemide - an MAOI Type A?, posted by Jaime on May 12, 1999, at 8:06:38
Moclobemide has been available in Australia for some time. I have had much success in treating mild depression. The side effects are minimal at a dose of 300-450mg. Zoloft (or other SSRIs) such as Prozac had much greater side effects in comparison. It works for me.
> > Has anyone taken Moclobemide (Manerix or Aurorix) with any success? I've read that the Type A's tend to deal more with mood elevation and (do I dare even suggest) "happiness."
> >
> > Does anyone else out there blow out their birthday candles or see the first star in the evening sky and wish for "happy" like I do?
> >
> > I was excited when I read about Moclobemide but had my bubble burst when my doctor wouldn't allow it because it's not approved in the US by the FDA.
Posted by Tom on August 8, 1999, at 19:26:34
In reply to Re: What about Moclobemide - an MAOI Type A?, posted by Adrian on August 8, 1999, at 5:18:43
>Is it possible to get some in the US??
Moclobemide has been available in Australia for some time. I have had much success in treating mild depression. The side effects are minimal at a dose of 300-450mg. Zoloft (or other SSRIs) such as Prozac had much greater side effects in comparison. It works for me.
>
>
> > > Has anyone taken Moclobemide (Manerix or Aurorix) with any success? I've read that the Type A's tend to deal more with mood elevation and (do I dare even suggest) "happiness."
> > >
> > > Does anyone else out there blow out their birthday candles or see the first star in the evening sky and wish for "happy" like I do?
> > >
> > > I was excited when I read about Moclobemide but had my bubble burst when my doctor wouldn't allow it because it's not approved in the US by the FDA.
Posted by robin on August 9, 1999, at 8:46:35
In reply to Re: What about Moclobemide - an MAOI Type A?, posted by Tom on August 8, 1999, at 19:26:34
> >Is it possible to get some in the US??
>
>
> Moclobemide has been available in Australia for some time. I have had much success in treating mild depression. The side effects are minimal at a dose of 300-450mg. Zoloft (or other SSRIs) such as Prozac had much greater side effects in comparison. It works for me.
> >
> >
> > > > Has anyone taken Moclobemide (Manerix or Aurorix) with any success? I've read that the Type A's tend to deal more with mood elevation and (do I dare even suggest) "happiness."
> > > >
> > > > Does anyone else out there blow out their birthday candles or see the first star in the evening sky and wish for "happy" like I do?
> > > >
> > > > I was excited when I read about Moclobemide but had my bubble burst when my doctor wouldn't allow it because it's not approved in the US by the FDA.What is the difference between a type A or B Maoi? If type A helps with your mood what does type B help with?
Thanks,
Robin
Posted by Adam on August 9, 1999, at 16:58:39
In reply to Re:MAOI Type A or B?, posted by robin on August 9, 1999, at 8:46:35
> What is the difference between a type A or B Maoi? If type A helps with your mood what does type B help with?
>
> Thanks,
> RobinMAO-A is found throughout the body, including the gut, and largely deaminates
serotonin and norepinepherine (as well as tyramine in the gut), though it does
have some low and non-specific activity on dopamine. MAO-B is found in the brain
and primarily deamniates dopamine.I have read that inhibition of MAO-B alone is not sufficient for the treatment of
depression, and in the case of selegiline, low doses (5mg/day, when there is only
inhibition of MAO-B) are not sufficient for that indication. However, selegiline
has been shown to be efficacious at higher doses, where MAO-A is also inhibited.
There may be a benefit in the dopaminergic effects of selegiline in addition to
its serotonergic and norepinepherinergic effects. For example, as some have posted
above, it may improve some cognitive functioning and sex drive.This is all anecdotal, of course. I have seen nothing in the literature that clearly
demonstrates that a robust dopaminergic effect is of any real benefit in treating
depression.
Posted by Adam on August 9, 1999, at 19:23:10
In reply to Re:MAOI Type A or B?, posted by Adam on August 9, 1999, at 16:58:39
In my last post, what I meant to say was "I have seen nothing in the literature that clearly demonstrates
that THE robust dopaminergic effect is of any real benefit in treating depression", meaning the MAO-B
inhibatory effects of selegiline. Many drugs that are "dopaminergics" like ritalin and amineptine have
been shown to be effective in treating depression, sometimes alone, or sometimes in combination with
other drugs. I apologise for my poor choice of wording.>
> > What is the difference between a type A or B Maoi? If type A helps with your mood what does type B help with?
> >
> > Thanks,
> > Robin
>
> MAO-A is found throughout the body, including the gut, and largely deaminates
> serotonin and norepinepherine (as well as tyramine in the gut), though it does
> have some low and non-specific activity on dopamine. MAO-B is found in the brain
> and primarily deamniates dopamine.
>
> I have read that inhibition of MAO-B alone is not sufficient for the treatment of
> depression, and in the case of selegiline, low doses (5mg/day, when there is only
> inhibition of MAO-B) are not sufficient for that indication. However, selegiline
> has been shown to be efficacious at higher doses, where MAO-A is also inhibited.
> There may be a benefit in the dopaminergic effects of selegiline in addition to
> its serotonergic and norepinepherinergic effects. For example, as some have posted
> above, it may improve some cognitive functioning and sex drive.
>
> This is all anecdotal, of course. I have seen nothing in the literature that clearly
> demonstrates that a robust dopaminergic effect is of any real benefit in treating
> depression.
Posted by D.C on August 11, 1999, at 8:17:36
In reply to Re:MAOI Type A or B?, posted by Adam on August 9, 1999, at 19:23:10
>
It doesn't do squat compared to the other MAOI's. Yeah I've heard about all the supposed health benefits, intelligence boosting etc. It strikes me as rather odd. Ritalin is more likely to get your mind pumping from what I hear. I don't know though maybe it's just my own biochemistry. It would be nice though to get a drug that could boost your brain power. Anyone know of any?
In my last post, what I meant to say was "I have seen nothing in the literature that clearly demonstrates
> that THE robust dopaminergic effect is of any real benefit in treating depression", meaning the MAO-B
> inhibatory effects of selegiline. Many drugs that are "dopaminergics" like ritalin and amineptine have
> been shown to be effective in treating depression, sometimes alone, or sometimes in combination with
> other drugs. I apologise for my poor choice of wording.
>
> >
> > > What is the difference between a type A or B Maoi? If type A helps with your mood what does type B help with?
> > >
> > > Thanks,
> > > Robin
> >
> > MAO-A is found throughout the body, including the gut, and largely deaminates
> > serotonin and norepinepherine (as well as tyramine in the gut), though it does
> > have some low and non-specific activity on dopamine. MAO-B is found in the brain
> > and primarily deamniates dopamine.
> >
> > I have read that inhibition of MAO-B alone is not sufficient for the treatment of
> > depression, and in the case of selegiline, low doses (5mg/day, when there is only
> > inhibition of MAO-B) are not sufficient for that indication. However, selegiline
> > has been shown to be efficacious at higher doses, where MAO-A is also inhibited.
> > There may be a benefit in the dopaminergic effects of selegiline in addition to
> > its serotonergic and norepinepherinergic effects. For example, as some have posted
> > above, it may improve some cognitive functioning and sex drive.
> >
> > This is all anecdotal, of course. I have seen nothing in the literature that clearly
> > demonstrates that a robust dopaminergic effect is of any real benefit in treating
> > depression.
Posted by Elizabeth on August 11, 1999, at 13:33:13
In reply to Re:MAOI Type A or B?, posted by Adam on August 9, 1999, at 16:58:39
> This is all anecdotal, of course. I have seen nothing in the literature that clearly
> demonstrates that a robust dopaminergic effect is of any real benefit in treating
> depression.One word: nomifensine!
Posted by Adam on August 11, 1999, at 16:49:09
In reply to Re: MAOI Type A or B?, posted by Elizabeth on August 11, 1999, at 13:33:13
Yeah, sorry! I tried to correct myself in my last post, but you're right, that
statement is incorrect.
> > This is all anecdotal, of course. I have seen nothing in the literature that clearly
> > demonstrates that a robust dopaminergic effect is of any real benefit in treating
> > depression.
>
> One word: nomifensine!
Posted by Adam on August 11, 1999, at 17:42:15
In reply to Selegeline doesn't do squat., posted by D.C on August 11, 1999, at 8:17:36
Hey, DC,
By saying "it doesn't do squat compared to the other MOII's", I'm assuming you mean it doesn't do squat for you. It might help other
people a great deal, though I have read in some places that selegiline seems to not have the mood-elevating power of the other MAOIs.
the folks I am working with at McLean seem to feel that it is a robust antidepressant, when used at the proper doses.
>
>
> It doesn't do squat compared to the other MAOI's. Yeah I've heard about all the supposed health benefits, intelligence boosting etc. It strikes me as rather odd. Ritalin is more likely to get your mind pumping from what I hear. I don't know though maybe it's just my own biochemistry. It would be nice though to get a drug that could boost your brain power. Anyone know of any?
>
>
>
>
>
>
>
>
Posted by Adam on August 15, 1999, at 18:32:27
In reply to Selegiline for depression?, posted by Brandon on May 10, 1999, at 23:07:11
For anyone who is curious:
I have been involved with the transdermal selegiline study for about 2 1/2 weeks now.
I have experienced no benefit whatsoever, and a slight decline in my mood. Side effects
seem to be minimal. I'm having a little trouble sleeping, but this has always been a
problem with me, and not that I'm off Remeron, I wouldn't expect to be sleeping as well.It may be that I'm on placebo. Time will tell.
> Has anyone heard of selegiline for depression. I have heard that it can be helpful.
Posted by Annie on August 15, 1999, at 22:21:25
In reply to Re: Selegiline for depression?, posted by Adam on August 15, 1999, at 18:32:27
Hang in there Adam! I finished a patch study 8 days ago. I felt worse until week 5 or 6 and then it kicked in! I'm sorry the study is over. It was my first depression break in years.
Annie> For anyone who is curious:
>
> I have been involved with the transdermal selegiline study for about 2 1/2 weeks now.
> I have experienced no benefit whatsoever, and a slight decline in my mood. Side effects
> seem to be minimal. I'm having a little trouble sleeping, but this has always been a
> problem with me, and not that I'm off Remeron, I wouldn't expect to be sleeping as well.
>
> It may be that I'm on placebo. Time will tell.
>
>
>
> > Has anyone heard of selegiline for depression. I have heard that it can be helpful.
Posted by Adam on August 16, 1999, at 17:02:35
In reply to Re: Selegiline for depression?Adam, posted by Annie on August 15, 1999, at 22:21:25
Hey, Annie,
I was wondering, what sort of side effects did you experience on
selegiline? I think I may be experiencing mild, um, difficulties.If that's all I get out of this, I'll be a dissappointed guy. I'll
try and hang in there, though. For the past couple months I've been
doing OK, if a bit anhedonic, and to have some real depressive symptoms
come back has been a frightening experience. One thing I hoped for
was this super-quick onset of antidepressant effect that the patch
system was supposed to deliver. If I'm on the drug, I'm not seeing it,
that's for damn sure. If I had to make a guess, this stuff might be
aggravating things. I wish I knew for sure.Ah, the joys of double-blinded clinical trials...the open label segment
is five weeks away. Yikes!> Hang in there Adam! I finished a patch study 8 days ago. I felt worse until week 5 or 6 and then it kicked in! I'm sorry the study is over. It was my first depression break in years.
> Annie
>
> > For anyone who is curious:
> >
> > I have been involved with the transdermal selegiline study for about 2 1/2 weeks now.
> > I have experienced no benefit whatsoever, and a slight decline in my mood. Side effects
> > seem to be minimal. I'm having a little trouble sleeping, but this has always been a
> > problem with me, and not that I'm off Remeron, I wouldn't expect to be sleeping as well.
> >
> > It may be that I'm on placebo. Time will tell.
> >
> >
> >
> > > Has anyone heard of selegiline for depression. I have heard that it can be helpful.
Posted by Annie on August 16, 1999, at 22:07:01
In reply to Re: Selegiline for depression?Annie, posted by Adam on August 16, 1999, at 17:02:35
Adam
I was in the double blind study first (no improvement for me), then went into the open label 30mg. The initial symptoms were greatly increased anxiety and urinary urgency. I'd be in the middle of a sentence and suddenly have to run like mad to the closest 'facility'. Oh yes I had a little blurry vision. These went away and constipation was the only physical side effect and it wasn't horrible. My word retrieval on Selegiline was absolutely terrible. I couldn't remember the name of common objects. The good part was that my metabolism kicked in and I started to lose weight effortlessly. My reaction to stress improved dramatically and I stopped having suicidal ideations. My energy level increased but then seemed to level out. The anhedonia remained, but I felt like I was in heaven compared to where I had been for years. I hope they have a dosage higher than 30 mg because I would return to the patch in an instant if it were available now. I hope it is as good for you -or even better!
Annie> Hey, Annie,
>
> I was wondering, what sort of side effects did you experience on
> selegiline? I think I may be experiencing mild, um, difficulties.
>
> If that's all I get out of this, I'll be a dissappointed guy. I'll
> try and hang in there, though. For the past couple months I've been
> doing OK, if a bit anhedonic, and to have some real depressive symptoms
> come back has been a frightening experience. One thing I hoped for
> was this super-quick onset of antidepressant effect that the patch
> system was supposed to deliver. If I'm on the drug, I'm not seeing it,
> that's for damn sure. If I had to make a guess, this stuff might be
> aggravating things. I wish I knew for sure.
>
> Ah, the joys of double-blinded clinical trials...the open label segment
> is five weeks away. Yikes!
>
> > Hang in there Adam! I finished a patch study 8 days ago. I felt worse until week 5 or 6 and then it kicked in! I'm sorry the study is over. It was my first depression break in years.
> > Annie
> >
> > > For anyone who is curious:
> > >
> > > I have been involved with the transdermal selegiline study for about 2 1/2 weeks now.
> > > I have experienced no benefit whatsoever, and a slight decline in my mood. Side effects
> > > seem to be minimal. I'm having a little trouble sleeping, but this has always been a
> > > problem with me, and not that I'm off Remeron, I wouldn't expect to be sleeping as well.
> > >
> > > It may be that I'm on placebo. Time will tell.
> > >
> > >
> > >
> > > > Has anyone heard of selegiline for depression. I have heard that it can be helpful.
Posted by Bones on August 17, 1999, at 12:12:10
In reply to Re: What about Moclobemide - an MAOI Type A?, posted by Adrian on August 8, 1999, at 5:18:43
> I tried Manerix for my OCD/Social Anxiety double combo. (What fun.) I was much brighter, and cognisant than with the SSRI's. It worked well for my social anxiety, I became more a "talker" than the "good listener" I've been. I liked it a lot. However, the lowered sensitivity to rejection that the SSRI's give wasn't enhanced. So I could speak clearer, wasn't shaky, but still ruminated about what people thought. (Bit of a bummer.) Gave me lots of energy too. Unfortunately, it didn't do wonders for my OCD - I had another bad bout when I was on it, and decided to come off. I would recommend anyone with Social Anxiety to give it a try.
Moclobemide has been available in Australia for some time. I have had much success in treating mild depression. The side effects are minimal at a dose of 300-450mg. Zoloft (or other SSRIs) such as Prozac had much greater side effects in comparison. It works for me.
>
>
> > > Has anyone taken Moclobemide (Manerix or Aurorix) with any success? I've read that the Type A's tend to deal more with mood elevation and (do I dare even suggest) "happiness."
> > >
> > > Does anyone else out there blow out their birthday candles or see the first star in the evening sky and wish for "happy" like I do?
> > >
> > > I was excited when I read about Moclobemide but had my bubble burst when my doctor wouldn't allow it because it's not approved in the US by the FDA.
Posted by Robin on August 17, 1999, at 12:51:41
In reply to Re: What about Moclobemide - an MAOI Type A?, posted by Bones on August 17, 1999, at 12:12:10
Has anyone tried both Parnate and selegiline? Can anyone compare these? I tried Marplan and hated it. It made me sleepy and I gained 8 pounds in one month. I am trying to decide which to try next of these 2 ADs.
Posted by dj on August 17, 1999, at 13:22:11
In reply to Re: What about Moclobemide - an MAOI Type A?, posted by Tom on August 8, 1999, at 19:26:34
Are Moclobemide & Manerix the same thing? Is it available in Canada? Is it useful for moderate to severe depression and if so in what dosages and what potential impacts??? Comments, insights, experiences, please....!!!
> Moclobemide has been available in Australia for some time. I have had much success in treating mild depression. The side effects are minimal at a dose of 300-450mg. Zoloft (or other SSRIs) such as Prozac had much greater side effects in comparison. It works for me.
> >
> >
> > > > Has anyone taken Moclobemide (Manerix or Aurorix) with any success? I've read that the Type A's tend to deal more with mood elevation and (do I dare even suggest) "happiness."
>
Posted by JohnL on August 18, 1999, at 2:36:44
In reply to Re: What about Moclobemide - ie. Manerix in Cda???, posted by dj on August 17, 1999, at 13:22:11
> Are Moclobemide & Manerix the same thing? Is it available in Canada? Is it useful for moderate to severe depression and if so in what dosages and what potential impacts??? Comments, insights, experiences, please....!!!
Yes. They are the same thing, different names. It is available in Canada. It is for all kinds of depressions. Effective dosages I believe begin at the 450mg range. My body didn't agree with it at all, which I think is rare, so can't comment much on experiences. I live in Maine, but got the prescrip in Montreal, and they can ship it to USA if the doc fills out special customs forms. Where do you live? JohnL.
Posted by dj on August 18, 1999, at 7:49:58
In reply to Re: What about Moclobemide - ie. Manerix in Cda???, posted by JohnL on August 18, 1999, at 2:36:44
Thanks for your comments JL. I'm in Vancouver.
Have you or do you take any SSRIs and if so what sort of reaction do you have to them???
> > I live in Maine, but got the prescrip in Montreal, and they can ship it to USA if the doc fills out special customs forms. Where do you live? JohnL.
Posted by Elizabeth on August 18, 1999, at 21:00:38
In reply to Parnate or selegiline?, posted by Robin on August 17, 1999, at 12:51:41
> Has anyone tried both Parnate and selegiline? Can anyone compare these? I tried Marplan and hated it. It made me sleepy and I gained 8 pounds in one month. I am trying to decide which to try next of these 2 ADs.
Selegiline caused more weight loss.
Parnate caused more cardiovascular effects (dizziness, transient elevations in BP, etc.).
Selegiline caused more insomnia and anxiety, while Parnate helped with anxiety.
Parnate worked, selegiline didn't.
I think that's it.
Posted by Robin on August 19, 1999, at 0:24:38
In reply to Re: Parnate or selegiline?, posted by Elizabeth on August 18, 1999, at 22:50:11
> > Has anyone tried both Parnate and selegiline? Can anyone compare these? I tried Marplan and hated it. It made me sleepy and I gained 8 pounds in one month. I am trying to decide which to try next of these 2 ADs.
>
> Selegiline caused more weight loss.
>
> Parnate caused more cardiovascular effects (dizziness, transient elevations in BP, etc.).
>
> Selegiline caused more insomnia and anxiety, while Parnate helped with anxiety.
>
> Parnate worked, selegiline didn't.
>
> I think that's it.Elizabeth, Thank you for the information. Could you tell me what dose of selegiline you were on?
Thank You Robin
Posted by Elizabeth on August 19, 1999, at 15:30:16
In reply to Re: Parnate or selegiline?, posted by Robin on August 19, 1999, at 0:24:38
> Elizabeth, Thank you for the information. Could you tell me what dose of selegiline you were on?
It was 40mg, and you're welcome.
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