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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by Matt on March 6, 1999, at 18:23:00
I guess that many pdocs recently have been rediscovering the TCA amoxapine. It has interesting serotonin and dopamine blocking effects (the latter to an extent to where one can get EPS and even TD on the medicine). I've just added 50mg of it to my 20mg Celexa, and I noticed an *immediate* improvement in my depression. I've taken lots of psychotropics, and except for benzos I've not encountered one that worked so quickly for me.
Matt
Posted by jim on March 9, 1999, at 4:50:16
In reply to positive amoxapine experience, posted by Matt on March 6, 1999, at 18:23:00
I wonder if this is because of the dopamine blocking... Had you ever tried MAOIs like nardil or parnate, which block dopamine uptake too?
Glad it's working for you!
--Jim> I guess that many pdocs recently have been rediscovering the TCA amoxapine. It has interesting serotonin and dopamine blocking effects (the latter to an extent to where one can get EPS and even TD on the medicine). I've just added 50mg of it to my 20mg Celexa, and I noticed an *immediate* improvement in my depression. I've taken lots of psychotropics, and except for benzos I've not encountered one that worked so quickly for me.
>
> Matt
Posted by Elizabeth on March 9, 1999, at 23:27:07
In reply to Re: positive amoxapine experience, posted by jim on March 9, 1999, at 4:50:16
Amoxapine isn't a dopamine *reuptake inhibitor*; it's a dopamine *antagonist*. That's what "blocks dopamine" means.
MAOIs don't "block dopamine." They increase the amount of dopamine available by inhibiting its metabolism.
I took amoxapine for 2 weeks or so, along with Parnate. It made me crave sugar to a point where I was really unfomfortable (must be what drug addicts feel like, I think), so I stopped. No other bad side effets, though, and no interaction with the Parnate.
-elizabeth
Posted by Jim on March 10, 1999, at 17:49:57
In reply to Re: positive amoxapine experience, posted by Elizabeth on March 9, 1999, at 23:27:07
Elizabeth wrote:
> Amoxapine isn't a dopamine *reuptake inhibitor*; it's a dopamine *antagonist*. That's what "blocks dopamine" means.
>
> MAOIs don't "block dopamine." They increase the amount of dopamine available by inhibiting its metabolism.
>
> I took amoxapine for 2 weeks or so, along with Parnate. It made me crave sugar to a point where I was really unfomfortable (must be what drug addicts feel like, I think), so I stopped. No other bad side effets, though, and no interaction with the Parnate.
>Whoops, my slip... Not knowing amoxapine very well
I stupidly read "dopamine (i.e., receptor) blocking" as
"dopamine reuptake blocking," which as you note is
still not exactly the mechanism of MAO inhibition
(although functionally roughly similar).
Pretty dense of me especially given that a dopamine
reuptake blocker wouldn't be associated with
a risk of extrapyramidal side-effects! Thanks
for setting my lapse straight on this one.
Hope all continues to go well with Matt, too!
-- Jim
This is the end of the thread.
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