Psycho-Babble Medication Thread 2229

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P450 drug interactions

Posted by Melanie on January 9, 1999, at 22:35:15

I recently attended a lecture on psychopharmacology
and learned that the SSRIs (with the exception of
the new one, Celexa) have a metabolite, cytochrome
P450 that causes Vicodin and Codeine to be less
effective when taken with the SSRIs (i.e. Paxil).
What can you tell me about this? I work as a Family
Nurse Practitioner in a chronic pain clinic where
a large majority of my patients are taking opiods as
well as anti-depressants.

Re: P450 drug interactions

Posted by Matt on January 14, 1999, at 19:24:10

In reply to P450 drug interactions, posted by Melanie on January 9, 1999, at 22:35:15

You might try http://www.btpnews.com/druginac.html

(got it from psych. tips.)

Matt

Re: P450 drug interactions

Posted by Elizabeth on January 18, 1999, at 8:20:55

In reply to Re: P450 drug interactions, posted by Matt on January 14, 1999, at 19:24:10

> You might try http://www.btpnews.com/druginac.html
> (got it from psych. tips.)
> Matt

This is one risk of combining SSRIs with other agents. I've been working on a web page of links relating to this subject; it's a work in progress, but you can read it at http://www.mit.edu/people/shapere/Drugs/links-kinetics.html. (I don't think the BTP site is on there; I should probably add it.)

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